Drug concentrations and interactions – therapeutic or toxic?
نویسندگان
چکیده
Undertaking toxicological analysis in clinical and post-mortem investigations can assist to determine the extent of drug contribution compliance, impairment, toxicity potentially death. The overlap blood concentrations following consumption be significant relying solely on a ‘number’ whether or not is therapeutic toxic difficult. Some poisons will at any measurable concentration, but for vast majority compounds which are detected routinely medico-legal casework, assessment case dependent many factors. These factors include limited dose, frequency, administration, interactions, natural disease some specific situations stability redistribution (i.e., post-mortem). This presentation provide an overview most important considerations better interpretation forensic toxicology results with demonstrated examples.
منابع مشابه
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متن کاملTherapeutic and toxic concentrations of more than 100 toxicologically significant drugs in blood, plasma, or serum: a tabulation.
The importance of determining concentrations of drugs in the blood, as well as the numerous modifying factors that play a role in the pharmacologic response to drugs, have been discussed in detail in this journal (1). Several authors have previously compiled data on therapeutic and toxic drug concentrations as aids in the interpretation of analytical results emanating from the laboratories of c...
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ژورنال
عنوان ژورنال: Pathology
سال: 2023
ISSN: ['1465-3931', '0031-3025']
DOI: https://doi.org/10.1016/j.pathol.2022.12.031